Search results for " Experimentation"
showing 10 items of 19 documents
Optimising experimental research in respiratory diseases: an ERS statement
2018
Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective.The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numb…
Carattere Universale. Innovazione senza Stile
2019
Il Bauhaus (1919-1933) ha segnato la storia. Questa scuola fu animata da alcuni degli artisti-progettisti più rilevanti del Novecento, da Gropius a Kandinskij, da Itten a Moholy-Nagy, non riconducibili a un approccio univoco. Eppure, l’idea del Bauhaus, che ha innervato il dibattito e la pratica del progetto in Europa e negli USA (e non solo) per decenni, si è risolta in una sorta di International Style che, nella tipografia, corrisponde al carattere Universal di Herbert Bayer (1925). Il presente articolo mira a evidenziare come il carattere universale, che raffigura per noi oggi lo ‘stile’ della Modernità, fu in principio innovazione allo stato puro: una configurazione volta all’effetto, a…
INNOVAZIONE DEI MATERIALI NATURALI: TERRA E NANOTUBI DI ARGILLA PER UNA SFIDA SOSTENIBILE
2019
All’interno del dibattito culturale che vede la questione ambientale come prioritaria e con riferimento a studi e ricerche che negli ultimi anni hanno promosso materiali compositi a base di terra cruda, gli Autori, consapevoli della necessità che il rapporto fra Progetto e Materia debba assumere una nuova centralità supportato dalle specificità della Tecnologia dell’Architettura, illustrano le risultanze di una sperimentazione che ha l’obiettivo di migliorare le prestazioni della terra cruda con l’apporto delle nanotecnologie, sviluppando un ‘nuovo materiale’ con una ridotta embodied energy e una ridotta quantità di emissioni di CO2 in atmosfera.
Periodontal impact of surgically induced dental lesions in mandibular osteodistraction: An animal study.
2009
SUMMARY. Aim: The objective of the study was to evaluatethe impact of dental lesions on the periodontium, in a canine model of mandibular osteodistraction. Material and methods: In six adult male Beagle dogs, an osteotomy was made between the right second lateral incisor and canine, and a distraction device placed. The roots adjacent to the osteotomy were deliberately damaged by the reciprocating saw and chisel, with preservation of the attached gingiva. The osteodistraction protocol used was: latency of 7 days, rate of distraction 1 mm per day, and rhythm once a day for 5 days. Vital staining was carried out with tetracycline, Xylenol Orange and Calcein Green. The dogs were sacrificed afte…
Impact of psychological risk factors on disaster rescue operations: the case of Italian volunteers.
2007
This paper reports on research into the characteristics of emergency rescue workers, with a focus on psychological distress. We present the results of a study of volunteers from the Italian national civil protection programme. A questionnaire was administered to 2,576 subjects from all over Italy. Most respondents were men, mostly unemployed, whose average level of education was higher than that among most Italian volunteers. Many were poorly endowed with basic skills, with large differences according to geography. Many expected to convert their volunteer activities into permanent jobs. Using this data, we employed a logistical regression model to analyse the risk of low, moderate and sever…
The protection of the person in medical research in the Spanish law.
2002
AbstractNo Abstract
Human surrogate models of neuropathic pain.
2005
Neuropathic pain is defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system (Merskey and Bogduk, 1994). Current efforts to refine this definition focus on the terms ‘dysfunction’ and ‘nervous system’ with the intention to clarify that there has to be an identifiable lesion or disease process affecting the somatosensory system. Experimental models of neuropathic pain according to either one of these definitions are expected to imitate mechanisms of nerve damage within the peripheral or central parts of the somatosensory system and the ensuing processes of degeneration and regeneration. Whereas this approach to model the etiology and pathophysiology of the…
Intravitreal Docosahexaenoic Acid in a Rabbit Model: Preclinical Safety Assessment
2014
PurposeThe purpose of the present study was to evaluate the retinal toxicity of a single dose of intravitreal docosahexaenoic acid (DHA) in rabbit eyes over a short-term period.MethodsSixteen New Zealand albino rabbits were selected for this pre-clinical study. Six concentrations of DHA (Brudy Laboratories, Barcelona, Spain) were prepared: 10 mg/50 µl, 5 mg/50 µl, 2'5 mg/50 µl, 50 µg/50 µl, 25 µg/50 µl, and 5 µg/50 µl. Each concentration was injected intravitreally in the right eye of two rabbits. As a control, the vehicle solution was injected in one eye of four animals. Retinal safety was studied by slit-lamp examination, and electroretinography. All the rabbits were euthanized one week a…
The effects of optimizing blood inflow in the pedicle on perforator flap survival: A pilot study in a rat model
2020
Background Perforator flaps have led to a revolution in reconstructive surgery by reducing donor site morbidity. However, many surgeons have witnessed partial flap necrosis. Experimental methods to increase inflow have relied on adding a separate pedicle to the flap. The aim of our study was to experimentally determine whether increasing blood flow in the perforator pedicle itself could benefit flap survival. Methods In 30 male Lewis rats, an extended posterior thigh perforator flap was elevated and the pedicle was dissected to its origin from the femoral vessels. The rats were assigned to three groups: control (group I), acute inflow (group II) and arterial preconditioning (group III) dep…